منابع مشابه
Amyotrophic lateral sclerosis and vascular risk: a metabolic conundrum.
Journal of Neurology Neurosurgery & Psychiatry (ISSN No: 0022-3050) is published monthly by BMJ Publishing Group and distributed in the USA by Mercury International Ltd. as mailing agent. Periodicals postage paid at Rahway, NJ. POSTMASTER: send address changes to Journal of Neurology Neurosurgery & Psychiatry, Mercury International Ltd, 365 Blair Road, Avenel, NJ, 07001, USA. Editorial commenta...
متن کاملmiR-33 Regulation of Adaptive Fibrotic Response in Cardiac Remodeling.
Despite substantial improvements in prevention, diagnosis, and therapeutic strategies, cardiovascular diseases remain the leading cause of mortality and morbidity worldwide. Cardiac fibrosis, a critical hallmark of maladaptive hypertrophy and heart failure (HF), is characterized by the excessive and uncontrolled accumulation of extracellular matrix (ECM) by cardiac fibroblasts (CFs) in the inte...
متن کاملMiR-33 connects cholesterol to the cell cycle
MicroRnAs (miRnAs) are non-coding RnAs that downregulate gene expression at the post-transcriptional level. in recent years, their regulatory roles have been receiving much attention. MiR33 is one such miRnA, recently identified as a critical regulator of cholesterol homeostasis1 and insulin signaling.2 The recent study by Cirera-salinas et al.3 described a new role of miR33 for the regulation ...
متن کاملTherapeutic Inhibition of miR-33 Promotes Fatty Acid Oxidation but Does Not Ameliorate Metabolic Dysfunction in Diet-Induced Obesity.
OBJECTIVE miR-33 has emerged as an important regulator of lipid homeostasis. Inhibition of miR-33 has been demonstrated as protective against atherosclerosis; however, recent studies in mice suggest that miR-33 inhibition may have adverse effects on lipid and insulin metabolism. Given the therapeutic interest in miR-33 inhibitors for treating atherosclerosis, we sought to test whether pharmacol...
متن کاملA developmental conundrum
Wnt signaling orchestrates morphogenetic processes in which changes in gene expression are associated with dramatic changes in cell organization within developing tissue/organs. Upon signaling, excess beta-catenin not utilized at cell-cell junctions becomes stabilized, where it can provide the transcriptional activating domain for Lef/Tcf DNA binding proteins. In skin epithelium, forced stabili...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2018
ISSN: 1043-2760
DOI: 10.1016/j.tem.2018.04.004